Article
Genotypes of the mannan-binding lectin gene and susceptibility to visceral leishmaniasis and clinical complications.
The Journal of infectious diseases - 15 Apr 2007
Alonso Diego Peres, Ferreira Afonso Flávio B, Ribolla Paulo Eduardo M, de Miranda Santos Isabel K F, do Socorro Pires e Cruz Maria, Aécio de Carvalho Fernando, Abatepaulo Antonio Roberto R, Lamounier Costa Dorcas, Werneck Guilherme L, Farias Teresinha J C, Soares Maria José S, Costa Carlos Henrique N
Abstract excerpt
BACKGROUND: Visceral leishmaniasis (VL) is almost always lethal if not treated, but most infections with the causative agents are clinically silent. Mannan-binding lectin (MBL), an opsonin, is a candidate molecule for modifying progression to VL because it may enhance infection with intracellular pathogens. Mutations in the MBL2 gene decrease levels of MBL and may protect against development of VL. This...
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