Article
Association of MBL2 Exon 1 Polymorphisms With Multibacillary Leprosy.
Frontiers in immunology - 1 Jan 2020
Tiyo Bruna Tiaki, Vendramini Evelyn Castillo Lima, de Souza Victor Hugo, Colli Cristiane Maria, Alves Hugo Vicentin, Sell Ana Maria, Zucoloto Sylmara Bessani Paixão, Visentainer Jeane Eliete Laguila
Abstract excerpt
Mannose-binding lectin (MBL) is a serum protein of innate immunity, with a central role in the activation of the complement system through the lectin pathway. This protein is encoded by MBL2 gene, and single-nucleotide polymorphisms located at exon 1, such as rs5030737 C>T (D variant), rs1800450 G>A (B variant), and rs1800451 G>A (C variant), may change the MBL structure and the serum concentration. MBL2...
Topics
- Adult
- Aged
- Brazil