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Article

Presynaptic dysfunction in Parkinson's disease: a focus on LRRK2.

Biochemical Society transactions - 1 Oct 2012

Belluzzi Elisa, Greggio Elisa, Piccoli Giovanni

Abstract excerpt

PD (Parkinson's disease) is a common neurodegenerative disease clinically characterized by bradykinesia, rigidity and resting tremor. Recent studies have proposed that synaptic dysfunction, implicated in numerous studies of animal models of PD, might be a key factor in PD. The molecular defects that lead to PD progression might be hidden at the presynaptic neuron: in fact accumulating evidence has shown that the...

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Identifiers

PMID: 22988874
DOI: 10.1042/BST20120124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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