Article
Role of LRRK2 in the regulation of dopamine receptor trafficking.
PloS one - 1 Jan 2017
Rassu Mauro, Del Giudice Maria Grazia, Sanna Simona, Taymans Jean Marc, Morari Michele, Brugnoli Alberto, Frassineti Martina, Masala Alessandra, Esposito Sonia, Galioto Manuela, Valle Cristiana, Carri Maria Teresa, Biosa Alice, Greggio Elisa, Crosio Claudia, Iaccarino Ciro
Abstract excerpt
Mutations in LRRK2 play a critical role in both familial and sporadic Parkinson's disease (PD). Up to date, the role of LRRK2 in PD onset and progression remains largely unknown. However, experimental evidence highlights a critical role of LRRK2 in the control of vesicle trafficking that in turn may regulate different aspects of neuronal physiology. We have analyzed the role of LRRK2 in regulating dopamine...
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