Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.

Nature communications - 19 Jul 2016

Penney Jay, Tsurudome Kazuya, Liao Edward H, Kauwe Grant, Gray Lindsay, Yanagiya Akiko, R Calderon Mario, Sonenberg Nahum, Haghighi A Pejmun

Abstract excerpt

Parkinson's disease gene leucine-rich repeat kinase 2 (LRRK2) has been implicated in a number of processes including the regulation of mitochondrial function, autophagy and endocytic dynamics; nevertheless, we know little about its potential role in the regulation of synaptic plasticity. Here we demonstrate that postsynaptic knockdown of the fly homologue of LRRK2 thwarts retrograde, homeostatic synaptic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Furin
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuromuscular Junction

Share to Neurotransmitter Agents

Share to RNA Caps

Share to Synapses

Share to Synaptic Transmission

Share to Synaptic Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 27432119
DOI: 10.1038/ncomms12188
PMCID: PMC4960312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.PMID 27432119Read ↗

TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction.Semantic proximity Read ↗

The synaptic function of LRRK2.Semantic proximity Read ↗

Role of LRRK2 in axonal transport and Parkinson's disease.Semantic proximity Read ↗

Identification of secretory autophagy as a novel mechanism modulating activity-induced synaptic remodelingSemantic proximity Read ↗

Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodelingSemantic proximity Read ↗

LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction.Semantic proximity Read ↗

Soma-centered control of synaptic autophagy by Rab39-regulated anterograde trafficking of Atg9Semantic proximity Read ↗

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursorsSemantic proximity Read ↗

LRRK2 at the pre‐synaptic site: A 16‐years perspectiveSemantic proximity Read ↗

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.Semantic proximity Read ↗

Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafishSemantic proximity Read ↗

Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafishSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.