Article
Phenotypic transformation of normal rat kidney cells by transforming growth factor beta is not paralleled by enhanced production of a platelet-derived growth factor.
European journal of biochemistry - 1 Oct 1992
van Zoelen E J, van Rotterdam W, Ward-Van Oostwaard T M, Feijen A
Abstract excerpt
Phenotypic transformation of normal rat kidney (NRK) cells requires the concerted action of multiple polypeptide growth factors. Serum-deprived NRK cells cultured in the presence of epidermal growth factor (EGF) become density-inhibited at confluence, but they can be restimulated by a number of defined polypeptide growth factors, resulting in phenotypic cellular transformation. Kinetic data show that...
Topics
- Animals
- Antibodies
- Blood
- Blotting, Northern
- Cell Count
- Cell Division
- Cell Line, Transformed
- Epidermal Growth Factor
- Gene Expression
- Kidney
- Kinetics