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Article

Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta.

Cellular signalling - 1 Apr 1998

Ota S, Kizaka-Kondoh S, Hashimoto Y, Nishihara H, Nagashima K, Kurata T, Okayama H, Matsuda M

Abstract excerpt

Crk belongs to the adapter proteins that participate in many signalling pathways from cell surface receptors. We have characterised the CrkII-23 mutant that inhibits the transformation of NRK cells induced by epidermal growth factor (EGF) and transforming growth factor (TGF)-beta. To study the biochemical difference, cDNAs of the wild-type CrkII and the CrkII-23 mutant were introduced stably into NIH 3T3 cells...

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Source

Identifiers

PMID: 9617486
DOI: 10.1016/s0898-6568(97)00130-7

Genes

EGF
EGFR
NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta.PMID 9617486Read ↗

[Inhibition of EGF and TGF-beta dependent transformation of NRK23 cells by Crk II-23 mutant].Semantic proximity Read ↗

CrkII signals from epidermal growth factor receptor to Ras.Semantic proximity Read ↗

Role of TGF-beta in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling.Semantic proximity Read ↗

Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration.Semantic proximity Read ↗

Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor.Semantic proximity Read ↗

Signal transduction cascade shared by epidermal growth factor and platelet-derived growth factor is a major pathway for oncogenic transformation in NRK cells.Semantic proximity Read ↗

The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-β signaling by inactivating the TGF-β type II receptorSemantic proximity Read ↗

CrkII induces serum response factor activation and cellular transformation through its function in Rho activation.Semantic proximity Read ↗

Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins.Semantic proximity Read ↗

A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation.Semantic proximity Read ↗

Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor.Semantic proximity Read ↗

The Rak/Frk tyrosine kinase associates with and internalizes the epidermal growth factor receptor.Semantic proximity Read ↗

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