Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta.

doi:10.1016/s0898-6568(97)00130-7

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Article

Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta.

Cellular signalling - 1 Apr 1998

Ota S, Kizaka-Kondoh S, Hashimoto Y, Nishihara H, Nagashima K, Kurata T, Okayama H, Matsuda M

Abstract excerpt

Crk belongs to the adapter proteins that participate in many signalling pathways from cell surface receptors. We have characterised the CrkII-23 mutant that inhibits the transformation of NRK cells induced by epidermal growth factor (EGF) and transforming growth factor (TGF)-beta. To study the bi...

Topics

3T3 Cells
Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Animals
COS Cells
Cell Differentiation
Cell Transformation, Neoplastic
DNA Mutational Analysis
Epidermal Growth Factor
ErbB Receptors
Eukaryotic Initiation Factor-2
Guanine Nucleotide Exchange Factors
Humans
Mice

Source

Open in PubMed

Identifiers

PMID: 9617486
DOI: 10.1016/s0898-6568(97)00130-7

Genes

EGF
EGFR
NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9617486-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutation

Neurons

PC12 Cells

Phosphorylation