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Article

Role of TGF-beta in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling.

FEBS letters - 21 Jan 2000

Kizaka-Kondoh S, Akiyama N, Okayama H

Abstract excerpt

We have been isolating and analyzing NRK cell mutants, which fail to transform by epidermal growth factor (EGF) and transforming growth factor (TGF)-beta. One such mutant, R14, can respond to the growth inhibitory signal of TGF-beta to the same extent as parental NRK but fail to respond to the growth stimulatory signal of EGF. This mutant has a defect in EGF receptor (EGFR) expression. When R14 mutant expressed a...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 10648833
DOI: 10.1016/s0014-5793(99)01784-6

Genes

EGF
EGFR
NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of TGF-beta in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling.PMID 10648833Read ↗

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