Article
Polyoma middle T antigen or v-src desensitizes human epidermal growth factor receptor function and interference by a monensin-resistant mutation in mouse Balb/3T3 cells.
Experimental cell research - 1 Dec 1992
Ono M, Nakayama Y, Princler G, Gopas J, Kung H F, Kuwano M
Abstract excerpt
Epidermal growth factor (EGF)-induced down-regulation of its receptor is an obligatory pathway for cellular regulation of EGF-specific receptor (EGF-R) in normal and malignant cells. BNER4 cells are mouse Balb/3T3 cells transfected with the human EGF-R complementary DNA (cDNA). Polyoma middle T a...
Topics
- 3T3 Cells
- Animals
- Antigens, Polyomavirus Transforming
- Base Sequence
- Cell Division
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- DNA
- Down-Regulation
- Drug Resistance
- Epidermal Growth Factor
- ErbB Receptors
- Genes, src
- Mice
- Molecular Sequence Data