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Article

Phenotypic transformation of normal rat kidney cells: a model for studying cellular alterations in oncogenesis.

Critical reviews in oncogenesis - 1 Jan 1991

van Zoelen E J

Abstract excerpt

The growth characteristics of cells in culture change dramatically upon tumorigenic transformation. By the use of selective culture media supplemented with growth factor-inactivated serum, the changes in requirements for externally added polypeptide growth factors can readily be assessed. Certain nontumorigenic cell lines, including normal rat kidney (NRK) fibroblasts, can obtain the growth characteristics of a...

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PMID: 1958713

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NRK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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