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Article

[Inhibition of EGF and TGF-beta dependent transformation of NRK23 cells by Crk II-23 mutant].

[Hokkaido igaku zasshi] The Hokkaido journal of medical science - 1 Jul 1997

Ota S

Abstract excerpt

Adaptor proteins participate in many signaling pathways from cell surface receptors. Crk protein was the first example of the adaptor protein. We have examined the function of Crk II mutant, Crk II-23. The Crk II-23 mutant contains two amino-acid substitutions in the carboxyl-terminal SH3 domain and is known to inhibit the transformation of NRK cells induced by epidermal growth factor (EGF) and transforming...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9266253

Genes

EGFR
EGF
NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Inhibition of EGF and TGF-beta dependent transformation of NRK23 cells by Crk II-23 mutant].PMID 9266253Read ↗

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A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein.Semantic proximity Read ↗

Role of TGF-beta in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling.Semantic proximity Read ↗

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