Article
Signal transduction cascade shared by epidermal growth factor and platelet-derived growth factor is a major pathway for oncogenic transformation in NRK cells.
The New biologist - 1 May 1992
Masuda A, Kizaka-Kondoh S, Miwatani H, Terada Y, Nojima H, Okayama H
Abstract excerpt
We have isolated two recessive, mutually complementary NRK cell mutants that are refractory to transformation by epidermal growth factor (EGF) and transforming growth factor-beta. Both mutants are defective in a signal transduction cascade shared by EGF and platelet-derived growth factor (PDGF). Analysis of the mutants suggests that transformation of NRK cells by the v-fms, v-erbB, activated erbB-2, v-ras, v-fos,...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Epidermal Growth Factor
- ErbB Receptors
- Gene Expression
- Mutation
- Oncogenes
- Platelet-Derived Growth Factor