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5-Hydroxymethylcytosine: the many faces of the sixth base of mammalian DNA

1 Jan 2024

Abstract excerpt

Epigenetic phenomena play a central role in cell regulatory processes and are important factors for understanding complex human disease. One of the best understood epigenetic mechanisms is DNA methylation. In the mammalian genome, cytosines (C) in CpG dinucleotides were long known to undergo methylation at the 5-position of the pyrimidine ring (mC). Later it was found that mC can be oxidized to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38205583
DOI: 10.1039/d3cs00858d

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