RGS-insensitive Gα subunits: probes of Gα subtype-selective signaling and physiological functions of RGS proteins.

Abstract excerpt

The Regulator of G protein Signaling (RGS) proteins were identified as a family in 1996 and humans have more than 30 such proteins. Their best known function is to suppress G Protein-Coupled Receptors (GPCR) signaling by increasing the rate of Gα turnoff through stimulation of GTPase activity (i.e., GTPase acceleration protein or GAP activity). The GAP activity of RGS proteins on the Gαi and Gαq family of G...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Targeting
• Share to Mutation
• Share to Protein Subunits