Article
Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2010
Németh Tamás, Futosi Krisztina, Hably Csilla, Brouns Madeleine R, Jakob Sascha M, Kovács Miklós, Kertész Zsuzsanna, Walzog Barbara, Settleman Jeffrey, Mócsai Attila
Abstract excerpt
Beta(2) integrins of neutrophils play a critical role in innate immune defense, but they also participate in tissue destruction during autoimmune inflammation. p190RhoGAP (ArhGAP35), a regulator of Rho family small GTPases, is required for integrin signal transduction in fibroblasts. Prior studies have also suggested a role for p190RhoGAP in beta(2) integrin signaling in neutrophils. To directly test that...
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