Article
An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2015
Hwang Il-Young, Park Chung, Harrison Kathleen, Boularan Cedric, Galés Céline, Kehrl John H
Abstract excerpt
Chemokines engage B lymphocyte surface receptors, triggering heterotrimeric G protein Gαi subunit guanine nucleotide exchange. RGS proteins limit the duration that Gαi subunits remain GTP bound, and the loss of an individual RGS protein typically enhances chemokine receptor signaling. In this study, we show that B cells carrying a Gαi2 (G184S/G184S) mutation that disables all RGS protein/Gαi2 interactions exhibit...
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