Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue.

Developmental cell - 18 Oct 2011

Deng Qing, Yoo Sa Kan, Cavnar Peter J, Green Julie M, Huttenlocher Anna

Abstract excerpt

Neutrophil homeostasis is essential for host defense. Here we identify dual roles for Rac2 during neutrophil homeostasis using a zebrafish model of primary immune deficiency induced by the human inhibitory Rac2D57N mutation in neutrophils. Noninvasive live imaging of Rac2 morphants or Rac2D57N ze...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agammaglobulinemia
Share to Bacterial Infections
Share to Hematopoietic System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HL-60 Cells

Share to Immunologic Deficiency Syndromes

Share to rac GTP-Binding Proteins

Share to Receptors, CXCR4

Source

Open in PubMed Open full text

Identifiers

PMID: 22014524
DOI: 10.1016/j.devcel.2011.07.013
PMCID: PMC3199325

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22014524-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue.PMID 22014524Read ↗

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.Semantic proximity Read ↗

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome.Semantic proximity Read ↗

A CRISPR/Cas9 vector system for neutrophil-specific gene disruption in zebrafishSemantic proximity Read ↗

Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophilsSemantic proximity Read ↗

Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish.Semantic proximity Read ↗

Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish.Semantic proximity Read ↗

Radil controls neutrophil adhesion and motility through β2-integrin activation.Semantic proximity Read ↗

Neutrophil migration: moving from zebrafish models to human autoimmunitySemantic proximity Read ↗

Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1BSemantic proximity Read ↗

Rac2 Hyperactivity Drives Neutrophil Degranulation, Myeloperoxidase Deficiency, and LymphopeniaSemantic proximity Read ↗

Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1BSemantic proximity Read ↗

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migrationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.