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Article

SRF is required for neutrophil migration in response to inflammation

27 Feb 2014

Abstract excerpt

Serum response factor (SRF) is a ubiquitously expressed transcription factor and master regulator of the actin cytoskeleton. We have previously shown that SRF is essential for megakaryocyte maturation and platelet formation and function. Here we elucidate the role of SRF in neutrophils, the primary defense against infections. To study the effect of SRF loss in neutrophils, we crossed Srf(fl/fl) mice with select...

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Identifiers

PMID: 24574460
DOI: 10.1182/blood-2013-06-507582

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