Article
Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs.
Journal of cellular biochemistry - 1 Feb 2013
Lim Do-Hwan, Lee Langho, Oh Chun-Taek, Kim Nam-Hoon, Hwang Seungwoo, Han Sung-Jun, Lee Young Sik
Abstract excerpt
RNA interference is a eukaryotic regulatory mechanism by which small non-coding RNAs typically mediate specific silencing of their cognate genes. In Drosophila, the RNase III enzyme Dicer-2 (Dcr-2) is essential for biogenesis of endogenous small interfering RNAs (endo-siRNAs), which have been implicated in regulation of endogenous protein-coding genes. Although much is known about microRNA-based regulatory...
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