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Article

Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila.

Biochemical and biophysical research communications - 4 Jul 2008

Lim Do Hwan, Kim Jung, Kim Sanguk, Carthew Richard W, Lee Young Sik

Abstract excerpt

The Drosophila RNase III enzyme Dicer-2 processes double-stranded RNA (dsRNA) precursors into small interfering RNAs (siRNAs). It also interacts with the siRNA product and R2D2 protein to facilitate the assembly of an RNA-induced silencing complex (RISC) that mediates RNA interference. Here, we characterized six independent missense mutations in the dicer-2 gene. Four mutations (P8S, L188F, R269W, and P365L) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 18454937
DOI: 10.1016/j.bbrc.2008.04.118
PMCID: PMC2924196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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