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Article

Gene expression profiling of U12-type spliceosome mutant Drosophila reveals widespread changes in metabolic pathways.

PloS one - 11 Oct 2010

Pessa Heli K J, Greco Dario, Kvist Jouni, Wahlström Gudrun, Heino Tapio I, Auvinen Petri, Frilander Mikko J

Abstract excerpt

BACKGROUND: The U12-type spliceosome is responsible for the removal of a subset of introns from eukaryotic mRNAs. U12-type introns are spliced less efficiently than normal U2-type introns, which suggests a rate-limiting role in gene expression. The Drosophila genome contains about 20 U12-type introns, many of them in essential genes, and the U12-type spliceosome has previously been shown to be essential in the...

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Identifiers

PMID: 20949011
DOI: 10.1371/journal.pone.0013215
PMCID: PMC2952598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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