Article
The RNAi pathway initiated by Dicer-2 in Drosophila.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2006
Kim K, Lee Y S, Harris D, Nakahara K, Carthew R W
Abstract excerpt
Injection or expression of double-stranded RNA (dsRNA) in Drosophila serves as a trigger that causes cells to specifically cleave homologous mRNA transcripts. Our approach is to identify essential components of the RNA interference (RNAi) mechanism by isolating and characterizing mutations that cause the RNAi response to be abnormal. These studies have thus far led to the identification of seven genetic loci that...
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