Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.

doi:10.1101/gad.927801

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Article

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.

Genes & development - 15 Oct 2001

Ketting R F, Fischer S E, Bernstein E, Sijen T, Hannon G J, Plasterk R H

Abstract excerpt

Double-stranded RNAs can suppress expression of homologous genes through an evolutionarily conserved process named RNA interference (RNAi) or post-transcriptional gene silencing (PTGS). One mechanism underlying silencing is degradation of target mRNAs by an RNP complex, which contains approximately 22 nt of siRNAs as guides to substrate selection. A bidentate nuclease called Dicer has been implicated as the...

Topics

Alleles
Animals
Animals, Genetically Modified
Caenorhabditis elegans
DNA Primers
Drosophila
Embryo, Nonmammalian
Endoribonucleases
Female
GPI-Linked Proteins
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Reporter

Germ Cells

Polymerase Chain Reaction

RNA, Antisense

RNA, Small Interfering

Rabbits

Receptors, Tumor Necrosis Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 11641272
DOI: 10.1101/gad.927801
PMCID: PMC312808

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