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Article

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.

Genes & development - 15 Oct 2001

Ketting R F, Fischer S E, Bernstein E, Sijen T, Hannon G J, Plasterk R H

Abstract excerpt

Double-stranded RNAs can suppress expression of homologous genes through an evolutionarily conserved process named RNA interference (RNAi) or post-transcriptional gene silencing (PTGS). One mechanism underlying silencing is degradation of target mRNAs by an RNP complex, which contains approximately 22 nt of siRNAs as guides to substrate selection. A bidentate nuclease called Dicer has been implicated as the...

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Identifiers

PMID: 11641272
DOI: 10.1101/gad.927801
PMCID: PMC312808

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