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Article

R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway.

Science (New York, N.Y.) - 26 Sept 2003

Liu Qinghua, Rand Tim A, Kalidas Savitha, Du Fenghe, Kim Hyun-Eui, Smith Dean P, Wang Xiaodong

Abstract excerpt

The RNA interference (RNAi) pathway is initiated by processing long double-stranded RNA into small interfering RNA (siRNA). The siRNA-generating enzyme was purified from Drosophila S2cells and consists of two stoichiometric subunits: Dicer-2(DCR-2) and a previously unknown protein that we named R2D2. R2D2 is homologous to the Caenorhabditis elegans RNAi protein RDE-4. Association with R2D2 does not affect the...

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PMID: 14512631
DOI: 10.1126/science.1088710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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