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Article

Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis.

Genes & development - 1 May 2020

Beebe Katherine, Robins Marcy M, Hernandez Edgar J, Lam Geanette, Horner Michael A, Thummel Carl S

Abstract excerpt

Metabolism and development must be closely coupled to meet the changing physiological needs of each stage in the life cycle. The molecular mechanisms that link these pathways, however, remain poorly understood. Here we show that the Drosophila estrogen-related receptor (dERR) directs a transcriptional switch in mid-pupae that promotes glucose oxidation and lipogenesis in young adults. dERR mutant adults are...

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Identifiers

PMID: 32165409
DOI: 10.1101/gad.335281.119
PMCID: PMC7197351

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