Article
Major histocompatibility complex-linked diabetogenic gene of the nonobese diabetic mouse. Analysis of genomic DNA amplified by the polymerase chain reaction.
The Journal of clinical investigation - 1 Jan 1990
Ikegami H, Eisenbarth G S, Hattori M
Abstract excerpt
Inheritance of insulin-dependent diabetes mellitus (IDDM) is polygenic, and at least one of the genes conferring susceptibility to diabetes is tightly linked to the MHC. Recent studies have suggested that DQB1 of humans and I-A beta of mice are closely associated with susceptibility and resistanc...
Topics
- Alleles
- Animals
- Base Sequence
- DNA
- Diabetes Mellitus, Experimental
- Genes
- Genetic Linkage
- Lymphocytes
- Major Histocompatibility Complex
- Mice
- Mice, Inbred ICR
- Mice, Mutant Strains
- Molecular Sequence Data
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Restriction Mapping
- Sequence Homology, Nucleic Acid