Article
Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse.
Annals of the New York Academy of Sciences - 1 Nov 2003
Ikegami Hiroshi, Fujisawa Tomomi, Makino Susumu, Ogihara Toshio
Abstract excerpt
Inheritance of type 1 diabetes is polygenic with a major susceptibility gene located in the major histocompatibility complex (MHC). In addition to MHC-linked susceptibility, a number of susceptibility genes have been mapped outside the MHC in both humans and animal models. In order to localize and identify susceptibility genes for type 1 diabetes, we have developed a series of congenic strains in which either...
Topics
- Animals
- Chromosome Mapping
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Humans
- Major Histocompatibility Complex
- Mice
- Mice, Inbred NOD