Article
Genetic analysis of autoimmune sialadenitis in nonobese diabetic mice: a major susceptibility region on chromosome 1.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2002
Boulard Olivier, Fluteau Guy, Eloy Laure, Damotte Diane, Bedossa Pierre, Garchon Henri-Jean
Abstract excerpt
The nonobese diabetic (NOD) mouse strain provides a good study model for Sjögren's syndrome (SS). The genetic control of SS was investigated in this model using different matings, including a (NOD x C57BL/6 (B6))F(2) cross, a (NOD x NZW)F(2) cross, and ((NOD x B6) x NOD) backcross. Multiple and different loci were detected depending on parent strain combination and sex. Despite significant complexity, two main...
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