Article
Characterizations of candidate genes for IDD susceptibility from the diabetes-prone NOD mouse strain.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 1993
Chesnut K, She J X, Cheng I, Muralidharan K, Wakeland E K
Abstract excerpt
The nucleotide sequences of the NOD and C57BL/6J alleles of Glut-2, Sod-2, and Il-2 were determined by RT-PCR sequencing. Each of these loci is located in intervals that strongly correlated with susceptibility to diabetes in an (NOD/Uf x C57BL/6J)F1 x NOD/Uf backcross. No significant variations i...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Crosses, Genetic
- DNA
- Diabetes Mellitus, Type 1
- Exons
- Genetic Predisposition to Disease
- Genetic Variation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Molecular Sequence Data
- Polymorphism, Genetic
