Article
MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3' boundary of the diabetogenic region.
Biochemical and biophysical research communications - 30 Apr 1993
Ikegami H, Kawaguchi Y, Ueda H, Fukuda M, Takakawa K, Fujioka Y, Fujisawa T, Uchida K, Ogihara T
Abstract excerpt
To localize and characterize the MHC-linked diabetogenic gene of the NOD mouse, we studied the class III region of the MHC in the NOD mouse and related strains. Hsp70, Bat5, Tnfa and Tnfb loci were studied by microsatellite polymorphism analysis and/or restriction mapping. The CTS mouse had the s...
Topics
- Animals
- DNA, Satellite
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Major Histocompatibility Complex
- Mice
- Mice, Inbred NOD
- Mice, Inbred Strains
- Polymorphism, Restriction Fragment Length
- Species Specificity