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Article

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

The Journal of experimental medicine - 1 Oct 1994

Serreze D V, Prochazka M, Reifsnyder P C, Bridgett M M, Leiter E H

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) in NOD/Lt mice represents a complex polygenic disease. NOR/Lt is a recombinant congenic strain (RCS) in which limited regions of the NOD/Lt genome have been replaced by genome from the C57BL/KsJ strain. NOR mice are insulitis resistant and diabetes free...

Topics

Alleles
Animals
Base Sequence
Chromosome Mapping
Diabetes Mellitus, Type 1
Female
Humans
Male
Mice
Mice, Inbred NOD
Molecular Sequence Data
Recombination, Genetic

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Identifiers

PMID: 7931087
DOI: 10.1084/jem.180.4.1553
PMCID: PMC2191696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7931087-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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