Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

The Journal of experimental medicine - 1 Oct 1994

Serreze D V, Prochazka M, Reifsnyder P C, Bridgett M M, Leiter E H

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) in NOD/Lt mice represents a complex polygenic disease. NOR/Lt is a recombinant congenic strain (RCS) in which limited regions of the NOD/Lt genome have been replaced by genome from the C57BL/KsJ strain. NOR mice are insulitis resistant and diabetes free despite genetic identity with NOD at numerous chromosomal regions containing previously described insulin-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Mice, Inbred NOD

Share to Molecular Sequence Data

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7931087
DOI: 10.1084/jem.180.4.1553
PMCID: PMC2191696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.PMID 7931087Read ↗

Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse.Semantic proximity Read ↗

Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits.Semantic proximity Read ↗

Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice.Semantic proximity Read ↗

Genotypic and phenotypic characterization of six new recombinant congenic strains derived from NOD/Shi and CBA/J genomes.Semantic proximity Read ↗

A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.Semantic proximity Read ↗

Genetic dissection of type 1 diabetes susceptibility gene, Idd3, by ancestral haplotype congenic mapping.Semantic proximity Read ↗

Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis.Semantic proximity Read ↗

Characterizations of candidate genes for IDD susceptibility from the diabetes-prone NOD mouse strain.Semantic proximity Read ↗

Crosses of NOD mice with the related NON strain. A polygenic model for IDDM.Semantic proximity Read ↗

A single recessive non-MHC diabetogenic gene determines the development of insulitis in the presence of an MHC-linked diabetogenic gene in NOD mice.Semantic proximity Read ↗

Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress.Semantic proximity Read ↗

TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.