Article
Genetic analysis of diabetes in the nonobese diabetic mouse. I. MHC and T cell receptor beta gene expression.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1991
Livingstone A, Edwards C T, Shizuru J A, Fathman C G
Abstract excerpt
Backcross nonobese diabetic (NOD) ((NOD x SWr)F1 x NOD) mice (108 females and 105 males) were typed for MHC, TCR V beta, and monitored for 350 days for the onset of diabetes. The presence of "antipolar" antibodies in the sera and the occurrence of insulitis was examined in a proportion of these backcross mice. There was no difference in the incidence of diabetes in mice heterozygous for TCR V beta b/a vs those...
Topics
- Animals
- Antibodies, Antinuclear
- Diabetes Mellitus, Experimental
- Diabetes Mellitus, Type 1
- Female
- Gene Expression
- Genotype
- Heterozygote
- Histocompatibility Antigens
- Homozygote
- Islets of Langerhans