A single recessive non-MHC diabetogenic gene determines the development of insulitis in the presence of an MHC-linked diabetogenic gene in NOD mice.

doi:10.1016/0896-8411(90)90002-a

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Article

A single recessive non-MHC diabetogenic gene determines the development of insulitis in the presence of an MHC-linked diabetogenic gene in NOD mice.

Journal of autoimmunity - 1 Feb 1990

Hattori M, Fukuda M, Ichikawa T, Baumgartl H J, Katoh H, Makino S

Abstract excerpt

To study the genetic control of insulitis in non-obese diabetic (NOD) mice, we performed breeding studies in crosses of NOD with non-diabetic strains, ICR-L-line Ishibe (ILI), non-obese non-diabetic (NON) and C3H/He mice. The ILI mouse serologically shared the same MHC Class I and Class II as the...

Topics

Animals
Crosses, Genetic
Diabetes Mellitus, Experimental
Female
Genes, Recessive
Genotype
Histocompatibility Antigens
Inflammation
Islets of Langerhans
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Mutant Strains
Skin Transplantation

Source

Open in PubMed

Identifiers

PMID: 2184821
DOI: 10.1016/0896-8411(90)90002-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2184821-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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