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Article

Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2010

Fraser Heather I, Dendrou Calliope A, Healy Barry, Rainbow Daniel B, Howlett Sarah, Smink Luc J, Gregory Simon, Steward Charles A, Todd John A, Peterson Laurence B, Wicker Linda S

Abstract excerpt

We have used the public sequencing and annotation of the mouse genome to delimit the previously resolved type 1 diabetes (T1D) insulin-dependent diabetes (Idd)18 interval to a region on chromosome 3 that includes the immunologically relevant candidate gene, Vav3. To test the candidacy of Vav3, we developed a novel congenic strain that enabled the resolution of Idd18 to a 604-kb interval, designated Idd18.1, which...

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Source

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Identifiers

PMID: 20363978
DOI: 10.4049/jimmunol.0903734
PMCID: PMC2886967

Genes

VAV3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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