Article
Implications of genetic heterogeneity in cancer.
Annals of the New York Academy of Sciences - 1 Sept 2012
Schmitt Michael W, Prindle Marc J, Loeb Lawrence A
Abstract excerpt
DNA sequencing studies have established that many cancers contain tens of thousands of clonal mutations throughout their genomes, which is difficult to reconcile with the very low rate of mutation in normal human cells. This observation provides strong evidence for the mutator phenotype hypothesis, which proposes that a genome-wide elevation in the spontaneous mutation rate is an early step in carcinogenesis. An...
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