Article
Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences.
Cancer research - 15 Apr 2016
Loeb Lawrence A
Abstract excerpt
The mutator phenotype hypothesis was postulated more than 40 years ago. It was based on the multiple enzymatic steps required to precisely replicate the 6 billion bases in the human genome each time a normal cell divides. A reduction in this accuracy during tumor progression could be responsible for the striking heterogeneity of malignant cells within a tumor and for the rapidity by which cancers become resistant...
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