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Article

Somatic mutation in cancer and normal cells.

Science (New York, N.Y.) - 25 Sept 2015

Martincorena Iñigo, Campbell Peter J

Abstract excerpt

Spontaneously occurring mutations accumulate in somatic cells throughout a person's lifetime. The majority of these mutations do not have a noticeable effect, but some can alter key cellular functions. Early somatic mutations can cause developmental disorders, whereas the progressive accumulation of mutations throughout life can lead to cancer and contribute to aging. Genome sequencing has revolutionized our...

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Identifiers

PMID: 26404825
DOI: 10.1126/science.aab4082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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