Article
Multiple mutations and cancer.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003
Loeb Lawrence A, Loeb Keith R, Anderson Jon P
Abstract excerpt
Most human tumors are highly heterogenous. We have hypothesized that this heterogeneity results from a mutator phenotype. Our premise is that normal mutation rates are insufficient to account for the multiple mutations found in human cancers, and, instead, that cancers must exhibit a mutator phenotype early during their evolution. Here, we examine the current status and implications of the mutator phenotype...
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