Article

Somatic mutability in cancer predicts the phenotypic relevance of germline mutations

2018-10-19

Abstract excerpt

Genomic sequence mutations in both the germline and somatic cells can be pathogenic. Several authors have observed that often the same genes are involved in cancer when mutated in somatic cells and in genetic diseases when mutated in the germline. Recent advances in high-throughput sequencing techniques have provided us with large databases of both types of mutations, allowing us to investigate this issue in a sys...

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Literature Corpus work: 43087359-cf76-5c37-bcc3-a8c89dcb5d0f
DOI: 10.1101/447862

Open publication

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