Article
Human cancers express a mutator phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2006
Bielas Jason H, Loeb Keith R, Rubin Brian P, True Lawrence D, Loeb Lawrence A
Abstract excerpt
Cancer cells contain numerous clonal mutations, i.e., mutations that are present in most or all malignant cells of a tumor and have presumably been selected because they confer a proliferative advantage. An important question is whether cancer cells also contain a large number of random mutations, i.e., randomly distributed unselected mutations that occur in only one or a few cells of a tumor. Such random...
Topics
- DNA, Single-Stranded
- Gene Expression
- Humans
- Mutation
- Neoplasms
- Phenotype