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Article

Human cancers express mutator phenotypes: origin, consequences and targeting.

Nature reviews. Cancer - 1 Jun 2011

Loeb Lawrence A

Abstract excerpt

Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by...

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Identifiers

PMID: 21593786
DOI: 10.1038/nrc3063
PMCID: PMC4007007

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