Article
The mutator phenotype in cancer: molecular mechanisms and targeting strategies.
Current drug targets - 1 Oct 2010
Prindle Marc J, Fox Edward J, Loeb Lawrence A
Abstract excerpt
Normal human cells replicate their DNA with exceptional accuracy. It has been estimated that approximately one error occurs during DNA replication for each 10(9) to 10(10) nucleotides polymerized. In contrast, malignant cells exhibit multiple chromosomal abnormalities and contain tens of thousands of alterations in the nucleotide sequence of nuclear DNA. To account for the disparity between the rarity of...
Topics
- Animals
- Antineoplastic Agents
- Base Sequence
- Chromosome Aberrations
- DNA Replication
- DNA, Neoplasm
- Drug Delivery Systems
- Drug Design
- Humans
- Mutation
- Neoplasms
- Phenotype