Article
Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses.
Human molecular genetics - 15 Nov 2012
Song Yiqing, Yeung Edwina, Liu Aiyi, Vanderweele Tyler J, Chen Liwei, Lu Chen, Liu Chunling, Schisterman Enrique F, Ning Yi, Zhang Cuilin
Abstract excerpt
The objective of the study is to quantify the causal effect of β-cell function on type 2 diabetes by minimizing residual confounding and reverse causation. We employed a Mendelian randomization (MR) approach using TCF7L2 variant rs7903146 as an instrument for lifelong levels of β-cell function. W...
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