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Article

Thyroid Signaling, Insulin Resistance, and 2 Diabetes Mellitus: A Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 1 Jun 2017

Bos Maxime M, Smit Roelof A J, Trompet Stella, van Heemst Diana, Noordam Raymond

Abstract excerpt

Context: Increasing evidence suggests an association between thyroid-stimulating hormone (TSH), free thyroxine (fT4), and deiodinases with insulin resistance and type 2 diabetes mellitus (T2D). Objective: We examined whether TSH and fT4 levels and deiodinases are causally associated with insulin resistance and T2D, using Mendelian randomization. Methods: We selected 20 genetic variants for TSH level and four for...

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Identifiers

PMID: 28323940
DOI: 10.1210/jc.2016-2816

Genes

DIO1
DIO2
DIO3

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