Article
BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization.
Diabetes - 1 Oct 2016
Corbin Laura J, Richmond Rebecca C, Wade Kaitlin H, Burgess Stephen, Bowden Jack, Smith George Davey, Timpson Nicholas J
Abstract excerpt
This study focused on resolving the relationship between BMI and type 2 diabetes. The availability of multiple variants associated with BMI offers a new chance to resolve the true causal effect of BMI on type 2 diabetes; however, the properties of these associations and their validity as genetic instruments need to be considered alongside established and new methods for undertaking Mendelian randomization (MR)....
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