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Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study.

EBioMedicine - 1 Apr 2016

Xu Min, Bi Yufang, Huang Ya, Xie Lan, Hao Mingli, Zhao Zhiyun, Xu Yu, Lu Jieli, Chen Yuhong, Sun Yimin, Qi Lu, Wang Weiqing, Ning Guang

Abstract excerpt

BACKGROUND: Type 2 diabetes (T2D) is a risk factor for dysregulation of glomerular filtration rate (GFR) and albuminuria. However, whether the association is causal remains unestablished. RESEARCH DESIGN AND METHODS: We performed a Mendelian Randomization (MR) analysis in 11,502 participants aged 40 and above, from a well-defined community in Shanghai during 2011-2013, to explore the causal association between...

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Albuminuria
China
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Glomerular Filtration Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Risk Assessment

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Identifiers

PMID: 27211558
DOI: 10.1016/j.ebiom.2016.02.032
PMCID: PMC4856750

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