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Article

Assessment of causality between serum gamma-glutamyltransferase and type 2 diabetes mellitus using publicly available data: a Mendelian randomization study.

International journal of epidemiology - 1 Dec 2016

Noordam Raymond, Smit Roelof Aj, Postmus Iris, Trompet Stella, van Heemst Diana

Abstract excerpt

Background: In observational studies, high levels of gamma-glutamyltransferase (GGT) have been associated with a higher risk of type 2 diabetes mellitus (T2D). We aimed to assess whether this association is causal, using Mendelian randomization. Methods: A Mendelian randomization study was conducted using publicly available data from a genome-wide association study (GWAS) on T2D (12 171 cases of T2D and 56 862...

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PMID: 28031309
DOI: 10.1093/ije/dyw306

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