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Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study

14 May 2019

Abstract excerpt

Liver dysfunction and type 2 diabetes (T2D) are consistently associated. However, it is currently unknown whether liver dysfunction contributes to, results from, or is merely correlated with T2D due to confounding. We used Mendelian randomization to investigate the presence and direction of any causal relation between liver function and T2D risk including up to 64,094 T2D case and 607,012 control subjects....

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PMID: 31088856
DOI: 10.2337/db18-1048

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