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Article

Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.

Investigative ophthalmology & visual science - 19 Sept 2012

Faber Carsten, Williams Jennifer, Juel Helene Bæk, Greenwood John, Nissen Mogens Holst, Moss Stephen E

Abstract excerpt

PURPOSE: The complement system is closely linked to the pathogenesis of AMD. Several complement genes are expressed in RPE, and complement proteins accumulate in drusen. Further, a common variant of complement factor H (CFH) confers increased risk of developing AMD. Because the mechanisms by which changes in the function of CFH influence development of AMD are unclear, we examined ocular complement expression as...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22918646
DOI: 10.1167/iovs.12-10385
PMCID: PMC3465015

Genes

CFH
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.PMID 22918646Read ↗

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