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Article

Complement Factor H: Spatial and Temporal Expression and Localization in the Eye

25 Aug 2006

Abstract excerpt

PURPOSE: Complement factor H (CFH) is a component of the mammalian complement system, which regulates the alternative pathway of complement activation and protects the host cell from inappropriate complement activation. CFH is a key regulator of innate immunity, and CFH deficiency leads to membranoproliferative glomerulonephritis type II. A variation in human CFH, Y402H, has been shown to be associated with an...

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PMID: 16936129
DOI: 10.1167/iovs.05-1655

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